Ontology highlight
ABSTRACT:
SUBMITTER: Okello M
PROVIDER: S-EPMC3846259 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Organic & biomolecular chemistry 20131007 45
The novel HIV-1 integrase inhibitor 1, discovered in our laboratory, exhibits potent anti-HIV activity against a diverse set of HIV-1 isolates and also against HIV-2 and SIV. In addition, this compound displays low cellular cytotoxicity and possesses a favorable in vitro drug interaction profile with respect to isozymes of cytochrome P450 (CYP) and uridine 5'-diphospho-glucuronosyltransferase (UGT). However, the total synthesis of this significant HIV integrase inhibitor has not been reported. T ...[more]