Ontology highlight
ABSTRACT:
SUBMITTER: Tamaru T
PROVIDER: S-EPMC3846904 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Tamaru Teruya T Hattori Mitsuru M Ninomiya Yasuharu Y Kawamura Genki G Varès Guillaume G Honda Kousuke K Mishra Durga Prasad DP Wang Bing B Benjamin Ivor I Sassone-Corsi Paolo P Ozawa Takeaki T Takamatsu Ken K
PloS one 20131202 12
Dysfunction of circadian clocks exacerbates various diseases, in part likely due to impaired stress resistance. It is unclear how circadian clock system responds toward critical stresses, to evoke life-protective adaptation. We identified a reactive oxygen species (ROS), H2O2 -responsive circadian pathway in mammals. Near-lethal doses of ROS-induced critical oxidative stress (cOS) at the branch point of life and death resets circadian clocks, synergistically evoking protective responses for cell ...[more]