Circadian clocks and metabolism.
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ABSTRACT:
SUBMITTER: Marcheva B
PROVIDER: S-EPMC4089089 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Publications
Circadian clocks and metabolism.
Marcheva Biliana B Ramsey Kathryn M KM Peek Clara B CB Affinati Alison A Maury Eleonore E Bass Joseph J
Handbook of experimental pharmacology 20130101 217
Circadian clocks maintain periodicity in internal cycles of behavior, physiology, and metabolism, enabling organisms to anticipate the 24-h rotation of the Earth. In mammals, circadian integration of metabolic systems optimizes energy harvesting and utilization across the light/dark cycle. Disruption of clock genes has recently been linked to sleep disorders and to the development of cardiometabolic disease. Conversely, aberrant nutrient signaling affects circadian rhythms of behavior. This chap ...[more]
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