Ontology highlight
ABSTRACT:
SUBMITTER: Iosue I
PROVIDER: S-EPMC3847328 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Iosue I I Quaranta R R Masciarelli S S Fontemaggi G G Batassa E M EM Bertolami C C Ottone T T Divona M M Salvatori B B Padula F F Fatica A A Lo-Coco F F Nervi C C Fazi F F
Cell death & disease 20131121
MicroRNAs are key regulators of many biological processes, including cell differentiation. These small RNAs exert their function assembled in the RNA-induced silencing complexes (RISCs), where members of Argonaute (Ago) family of proteins provide a unique platform for target recognition and gene silencing. Here, by using myeloid cell lines and primary blasts, we show that Ago2 has a key role in human monocytic cell fate determination and in LPS-induced inflammatory response of 1,25-dihydroxyvita ...[more]