Functional association between Wwox tumor suppressor protein and p73, a p53 homolog.
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ABSTRACT:
SUBMITTER: Aqeilan RI
PROVIDER: S-EPMC384759 | biostudies-literature | 2004 Mar
REPOSITORIES: biostudies-literature
Publications
Functional association between Wwox tumor suppressor protein and p73, a p53 homolog.
Aqeilan Rami I RI Pekarsky Yuri Y Herrero Juan J JJ Palamarchuk Alexey A Letofsky Jean J Druck Teresa T Trapasso Francesco F Han Shuang-Yin SY Melino Gerry G Huebner Kay K Croce Carlo M CM
Proceedings of the National Academy of Sciences of the United States of America 20040301 13
The WWOX gene is a recently cloned tumor suppressor gene that spans the FRA16D fragile region. Wwox protein contains two WW domains that are generally known to mediate protein-protein interaction. Here we show that Wwox physically interacts via its first WW domain with the p53 homolog, p73. The tyrosine kinase, Src, phosphorylates Wwox at tyrosine 33 in the first WW domain and enhances its binding to p73. Our results further demonstrate that Wwox expression triggers redistribution of nuclear p73 ...[more]
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