Ontology highlight
ABSTRACT:
SUBMITTER: Michel L
PROVIDER: S-EPMC384769 | biostudies-literature | 2004 Mar
REPOSITORIES: biostudies-literature
Michel Loren L Diaz-Rodriguez Elena E Narayan Gopeshwar G Hernando Eva E Murty Vundavalli V V S VV Benezra Robert R
Proceedings of the National Academy of Sciences of the United States of America 20040315 13
MAD2 inhibits the anaphase-promoting complex when chromosomes are unattached to the mitotic spindle. It acts as a tumor suppressor gene because MAD2+/-cells enter anaphase early and display chromosome instability, leading to the formation of lung tumors in mice. Complete MAD2 inactivation has not been identified in human tumors, although partial defects are prevalent. By employing RNA interference in human somatic cells, we found that severe reduction of MAD2 protein levels results in mitotic fa ...[more]