Ontology highlight
ABSTRACT:
SUBMITTER: Huh CG
PROVIDER: S-EPMC384772 | biostudies-literature | 2004 Mar
REPOSITORIES: biostudies-literature
Huh Chang-Goo CG Factor Valentina M VM Sánchez Aránzazu A Uchida Koichi K Conner Elizabeth A EA Thorgeirsson Snorri S SS
Proceedings of the National Academy of Sciences of the United States of America 20040301 13
Hepatocyte growth factor/scatter factor c-met signaling pathway is of central importance during development as well as in tumorigenesis. Because homozygous null mice for either hgf/sf or c-met die in utero, we used Cre/loxP-mediated gene targeting to investigate the function of c-met specifically in the adult liver. Loss of c-met appeared not to be detrimental to hepatocyte function under physiological conditions. Nonetheless, the adaptive responses of the liver to injury were dramatically affec ...[more]