Ontology highlight
ABSTRACT:
SUBMITTER: Licinio J
PROVIDER: S-EPMC384781 | biostudies-literature | 2004 Mar
REPOSITORIES: biostudies-literature
Licinio Julio J Caglayan Sinan S Ozata Metin M Yildiz Bulent O BO de Miranda Patricia B PB O'Kirwan Fiona F Whitby Robert R Liang Liyin L Cohen Pinchas P Bhasin Shalender S Krauss Ronald M RM Veldhuis Johannes D JD Wagner Anthony J AJ DePaoli Alex M AM McCann Samuel M SM Wong Ma-Li ML
Proceedings of the National Academy of Sciences of the United States of America 20040309 13
Genetic mutations in the leptin pathway can be a cause of human obesity. It is still unknown whether leptin can be effective in the treatment of fully established morbid obesity and its endocrine and metabolic consequences in adults. To test the hypothesis that leptin has a key role in metabolic and endocrine regulation in adults, we examined the effects of human leptin replacement in the only three adults identified to date who have genetically based leptin deficiency. We treated these three mo ...[more]