How does leptin restore euglycemia in insulin-deficient diabetes?
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ABSTRACT:
SUBMITTER: Oberlin D
PROVIDER: S-EPMC5272168 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
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How does leptin restore euglycemia in insulin-deficient diabetes?
Oberlin Douglas D Buettner Christoph C
The Journal of clinical investigation 20170123 2
Insulin replacement is the cornerstone of type 1 diabetes (T1D) treatment; however, glycemic control remains a challenge. Leptin has been shown to effectively restore euglycemia in rodent models of T1D; however, the mechanism or mechanisms by which leptin exerts glycemic control are unclear. In this issue of the JCI, Perry and colleagues provide evidence that suppression of lipolysis is a key facet of leptin-mediated restoration of euglycemia. However, more work remains to be done to fully under ...[more]
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