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How does leptin restore euglycemia in insulin-deficient diabetes?

ABSTRACT: Insulin replacement is the cornerstone of type 1 diabetes (T1D) treatment; however, glycemic control remains a challenge. Leptin has been shown to effectively restore euglycemia in rodent models of T1D; however, the mechanism or mechanisms by which leptin exerts glycemic control are unclear. In this issue of the JCI, Perry and colleagues provide evidence that suppression of lipolysis is a key facet of leptin-mediated restoration of euglycemia. However, more work remains to be done to fully understand the antidiabetic mechanisms of leptin.

SUBMITTER: Oberlin D

PROVIDER: S-EPMC5272168 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature

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How does leptin restore euglycemia in insulin-deficient diabetes?

Oberlin Douglas D Buettner Christoph C

The Journal of clinical investigation 20170123 2

Insulin replacement is the cornerstone of type 1 diabetes (T1D) treatment; however, glycemic control remains a challenge. Leptin has been shown to effectively restore euglycemia in rodent models of T1D; however, the mechanism or mechanisms by which leptin exerts glycemic control are unclear. In this issue of the JCI, Perry and colleagues provide evidence that suppression of lipolysis is a key facet of leptin-mediated restoration of euglycemia. However, more work remains to be done to fully under ...[more]

PMID: 28112680

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