Overlapping neural systems mediating extinction, reversal and regulation of fear.
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ABSTRACT:
SUBMITTER: Schiller D
PROVIDER: S-EPMC3848321 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Publications
Overlapping neural systems mediating extinction, reversal and regulation of fear.
Schiller Daniela D Delgado Mauricio R MR
Trends in cognitive sciences 20100520 6
Learned fear is a process allowing quick detection of associations between cues in the environment and prediction of imminent threat. Adaptive function in a changing environment, however, requires organisms to quickly update this learning and have the ability to hinder fear responses when predictions are no longer correct. Here we focus on three strategies that can modify conditioned fear, namely extinction, reversal and regulation of fear, and review their underlying neural mechanisms. By direc ...[more]
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