Unknown

Dataset Information

0

Standard and variant Philadelphia translocation in a CML patient with different sensitivity to imatinib therapy.


ABSTRACT: Most chronic myeloid leukemia (CML) patients show the Philadelphia chromosome (Ph) arising from the reciprocal t(9;22), but 5-10% present variants of this translocation involving different breakpoints besides 9q34 and 22q11. WE REPORT THE NON SIMULTANEOUS OCCURRENCE OF TWO DIFFERENT TYPES OF PH TRANSLOCATION IN A CML PATIENT: a t(9;22)(q34;q11) standard and a three-way variant t(9;11;22)(q34;p15;q11). Bone marrow cells with standard translocation did not have BCR/ABL kinase domain (KD) mutations and were sensitive to imatinib therapy. In contrast, bone marrow cells with the variant translocation showed two BCR/ABL KD mutations and were resistant to imatinib, thus inducing transformation to the blast phase and karyotype evolution.

SUBMITTER: Aliano S 

PROVIDER: S-EPMC3850369 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC5056971 | biostudies-literature
| S-EPMC4601872 | biostudies-literature
2008-07-30 | GSE12211 | GEO
2008-10-21 | E-GEOD-12211 | biostudies-arrayexpress
| S-EPMC8404470 | biostudies-literature
| S-EPMC2951856 | biostudies-literature
| S-EPMC4748686 | biostudies-literature
| S-EPMC3916877 | biostudies-literature
| S-EPMC2699476 | biostudies-literature
| S-EPMC5680612 | biostudies-literature