Ontology highlight
ABSTRACT:
SUBMITTER: Herborg LL
PROVIDER: S-EPMC3850390 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Herborg Laura Laine LL Nederby Line L Kjeldsen Eigil E Grønbæk Kirsten K Hokland Peter P Hansen Maria M Celik Hansen Marcus M Roug Anne Stidsholt AS
Leukemia research reports 20130704 2
Chronic myeloid neoplasms have susceptibility to transform into acute myeloid leukemia due to attainment of additional molecular lesions. We here describe the kinetics of a del(7q) driven leukemogenesis in a patient with multiple TET2 mutations and JAK2 V617F mutated chronic myeloproliferative neoplasm. The del(7q) emerged in the accelerated phase of disease, which was preceded by a lag phase of almost three years with normalized peripheral blood cell counts. Our results reveal that the del(7q), ...[more]