Ontology highlight
ABSTRACT:
SUBMITTER: Wang Q
PROVIDER: S-EPMC7645062 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Wang Qian Q Dai Hai-Ping HP Liu Dan-Dan DD Xie Jun-Dan JD Yao Hong H Ding Zi-Xuan ZX Tao Ting-Ting TT Chen Su-Ning SN Zhang Ri R
Leukemia research reports 20201030
Myelodysplastic/myeloproliferative neoplasm, unclassifiable (MDS/MPN-U) is a rare but heterogeneous subtype of MDS/MPN, with no specific genetic alterations and standard treatments. <i>ASXL1, SRSF2, TET2, JAK2</i> and <i>NRAS</i> are commonly mutated in MDS/MPN-U. Double gene mutations could be detected in MDS/MPN-U, however, co-mutations of 3 and more genes in this disease entity are very rare. Here, we present a case of MDS/MPN-U with triple mutations involving <i>JAK2, SF3B1</i>, and <i>TP53< ...[more]