Molecular evolution of threonine dehydratase in bacteria.
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ABSTRACT:
SUBMITTER: Yu X
PROVIDER: S-EPMC3851459 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Publications
Molecular evolution of threonine dehydratase in bacteria.
Yu Xuefei X Li Ye Y Wang Xiaoyuan X
PloS one 20131204 12
Threonine dehydratase converts L-threonine to 2-ketobutyrate. Several threonine dehydratases exist in bacteria, but their origins and evolutionary pathway are unknown. Here we analyzed all the available threonine dehydratases in bacteria and proposed an evolutionary pathway leading to the genes encoding three different threonine dehydratases CTD, BTD1 and BTD2. The ancestral threonine dehydratase might contain only a catalytic domain, but one or two ACT-like subdomains were fused during the evol ...[more]
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