Aligned human microvessels formed in 3D fibrin gel by constraint of gel contraction.
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ABSTRACT:
SUBMITTER: Morin KT
PROVIDER: S-EPMC3851923 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Publications
Aligned human microvessels formed in 3D fibrin gel by constraint of gel contraction.
Morin Kristen T KT Smith Annie O AO Davis George E GE Tranquillo Robert T RT
Microvascular research 20130809
This study aimed to form microvessels in fibrin gels, which is of interest both for studying the fundamental cell-matrix interactions as well as for tissue engineering purposes, and to align the microvessels, which would provide natural inlet and outlet sides for perfusion. The data reported here demonstrate the formation of highly interconnected microvessels in fibrin gel under defined medium conditions and the ability to align them using two methods, both of which involved anchoring the gel at ...[more]
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