Ontology highlight
ABSTRACT:
SUBMITTER: Yoshida K
PROVIDER: S-EPMC3853628 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Yoshida Kazuhiro K Okuzaki Yuya Y Nishijima Ken-Ichi K Kyogoku Kenji K Yamashita Takashi T Kawabe Yoshinori Y Motono Makoto M Kamihira Masamichi M Iijima Shinji S
Cytotechnology 20130719 6
The transgenic chicken is a candidate for the production of biopharmaceutical proteins with several economic superiorities. In general, the addition of sialic acid at the terminal of N-glycan is important for the bioactivity of biopharmaceuticals including plasma half-life; however, sialic acid has not been detected in the N-glycan of proteins produced in the egg white of genetically manipulated chickens. In this study, the extracellular domain of the TNF receptor and single chain Fv fused to Fc ...[more]