Ontology highlight
ABSTRACT:
SUBMITTER: Lee DS
PROVIDER: S-EPMC3853742 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Lee Dong-Sung DS Ko Wonmin W Quang Tran Hong TH Kim Kyoung-Su KS Sohn Jae Hak JH Jang Jae-Hyuk JH Ahn Jong Seog JS Kim Youn-Chul YC Oh Hyuncheol H
Marine drugs 20131112 11
In the course of studies on bioactive metabolites from marine fungi, a new 10-membered lactone, named penicillinolide A (1) was isolated from the organic extract of Penicillium sp. SF-5292 as a potential anti-inflammatory compound. The structure of penicillinolide A (1) was mainly determined by analysis of NMR and MS data and Mosher's method. Penicillinolide A (1) inhibited the production of NO and PGE2 due to inhibition of the expression of iNOS and COX-2. Penicillinolide A (1) also reduced TNF ...[more]