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New Andrastin-Type Meroterpenoids from the Marine-Derived Fungus Penicillium sp.

ABSTRACT: Three new andrastin-type meroterpenoids penimeroterpenoids A-C (1-3) together with two known analogs (4 and 5) were isolated from the cultures of the marine-derived Penicillium species (sp.). The structures of the new compounds were elucidated on the basis of 1- and 2-dimensional (1D/2D) Nuclear Magnetic Resonance (NMR) spectroscopic and mass spectrometric analysis. The absolute configurations of 1-3 were determined by comparison of experimental and calculated electronic circular dichroism (ECD) spectra. Compound 1 showed moderate cytotoxicity against A549, HCT116, and SW480 cell lines.

SUBMITTER: Ren J 

PROVIDER: S-EPMC8066695 | biostudies-literature |

REPOSITORIES: biostudies-literature

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