Unknown

Dataset Information

0

Association of rs12255372 in the TCF7L2 gene with type 2 diabetes mellitus: a meta-analysis.


ABSTRACT: Our objective was to evaluate the association of rs12255372 in the TCF7L2 gene with type 2 diabetes mellitus (T2DM) in the world population. We carried out a survey of the literature about the effect of rs12255372 on genetic susceptibility to T2DM by consulting PubMed, the Cochrane Library, and Embase from 2006 to 2012, and then performed a meta-analysis of all the studies in order to evaluate the association between rs12255372 and T2DM. A total of 33 articles including 42 studies (with 34,076 cases and 36,192 controls) were confirmed to be eligible and were included in the final meta-analysis: 6 studies conducted on Europeans, 14 on Caucasians, 17 on Asians, 2 on Africans, and 3 on Americans. Overall, the effect size was as follows: for the variant allele T (OR = 1.387, 95%CI = 1.351-1.424), for the TT genotype (OR = 1.933, 95%CI = 1.815-2.057), for the GT genotype (OR = 1.363, 95%CI = 1.315-1.413), for the dominant model (OR = 1.425, 95%CI = 1.344-1.510), and for the recessive model (OR = 1.659, 95%CI = 1.563-1.761). In summary, by pooling all available qualified data from genetic studies on rs12255372 and T2DM, we have confirmed that rs12255372 is significantly associated with susceptibility to T2DM in the global population.

SUBMITTER: Wang J 

PROVIDER: S-EPMC3854403 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature

altmetric image

Publications

Association of rs12255372 in the TCF7L2 gene with type 2 diabetes mellitus: a meta-analysis.

Wang Jinjin J   Zhang Jianfeng J   Li Linlin L   Wang Yan Y   Wang Qian Q   Zhai Yujia Y   You Haifei H   Hu Dongsheng D  

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20130412 4


Our objective was to evaluate the association of rs12255372 in the TCF7L2 gene with type 2 diabetes mellitus (T2DM) in the world population. We carried out a survey of the literature about the effect of rs12255372 on genetic susceptibility to T2DM by consulting PubMed, the Cochrane Library, and Embase from 2006 to 2012, and then performed a meta-analysis of all the studies in order to evaluate the association between rs12255372 and T2DM. A total of 33 articles including 42 studies (with 34,076 c  ...[more]

Similar Datasets

| S-EPMC3389527 | biostudies-literature
| S-EPMC4434239 | biostudies-literature
| S-EPMC5842570 | biostudies-literature
| S-EPMC5497039 | biostudies-literature
| S-EPMC2653476 | biostudies-literature
| S-EPMC8629679 | biostudies-literature
| S-EPMC3602305 | biostudies-literature
| S-EPMC4658796 | biostudies-literature
| S-EPMC3256145 | biostudies-literature
| S-EPMC4696988 | biostudies-literature