Unknown

Dataset Information

0

Association between the TCF7L2 rs12255372 (G/T) gene polymorphism and type 2 diabetes mellitus in a Cameroonian population: a pilot study.

ABSTRACT: BACKGROUND:To study the relationship between the rs12255372 (G/T) polymorphism of the transcription factor 7-like 2 (TCF7L2) and type 2 diabetes mellitus (T2DM) in a Cameroonian population. METHODS:This case-control study included 60 T2DM patients and 60 healthy normoglycemic controls, all unrelated and of Cameroonian origin, aged above 40 years (range 40-87). The Restriction Fragment Length Polymorphism - Polymerase Chain Reaction (RFLP-PCR) was used for genotyping. RESULTS:The T allele frequency was significantly higher in the diabetic group (0.44) than in the control group (0.17). This allele was significantly associated to a greater risk of developing T2DM as compared to the G allele (OR?=?3.92, 95% CI 2.04 - 7.67, p?

SUBMITTER: Nanfa D 

PROVIDER: S-EPMC4434239 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

<h4>Background</h4>To study the relationship between the rs12255372 (G/T) polymorphism of the transcription factor 7-like 2 (TCF7L2) and type 2 diabetes mellitus (T2DM) in a Cameroonian population.<h4>Methods</h4>This case-control study included 60 T2DM patients and 60 healthy normoglycemic controls, all unrelated and of Cameroonian origin, aged above 40 years (range 40-87). The Restriction Fragment Length Polymorphism - Polymerase Chain Reaction (RFLP-PCR) was used for genotyping.<h4>Results</h  ...[more]

Similar Datasets

Unknown Association of the TCF7L2 rs12255372 (G/T) variant with type 2 diabetes mellitus in an Iranian population.
| S-EPMC3389527 | biostudies-literature
Unknown Association between the rs12255372 variant of the TCF7L2 gene and obesity in a Cameroonian population.
| S-EPMC4658796 | biostudies-literature
Unknown Association of rs12255372 in the TCF7L2 gene with type 2 diabetes mellitus: a meta-analysis.
| S-EPMC3854403 | biostudies-literature
Unknown Association of the rs11196218 polymorphism in TCF7L2 with type 2 diabetes mellitus in Asian population.
| S-EPMC4287822 | biostudies-literature
Unknown Meta-analysis of association between TCF7L2 polymorphism rs7903146 and type 2 diabetes mellitus.
| S-EPMC5842570 | biostudies-literature
Unknown Investigation of the association between the TCF7L2 rs7903146 (C/T) gene polymorphism and obesity in a Cameroonian population: a pilot study.
| S-EPMC5395748 | biostudies-literature
Unknown Association of transcription factor 7-like 2 (TCF7L2) gene polymorphism with type 2 diabetes mellitus in Chinese Korean ethnicity population.
| S-EPMC6380799 | biostudies-literature
Unknown Association of TCF7L2 rs7903146 Polymorphism with the Risk of Type 2 Diabetes Mellitus (T2DM) Among Kurdish Population in Erbil Province, Iraq.
| S-EPMC8215002 | biostudies-literature
Unknown Association of TCF7L2 Genetic Polymorphisms with Type 2 Diabetes Mellitus in the Uygur Population of China.
| S-EPMC4586708 | biostudies-literature
Unknown Association of RAGE gene polymorphism with Type-2 diabetes mellitus in local population.
| S-EPMC5857018 | biostudies-literature