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Correlation between interleukin-18 promoter -607C/A polymorphism and susceptibility to ischemic stroke.

ABSTRACT: Single nucleotide polymorphisms in the promoter region of interleukin-18 (IL-18), an inflammatory cytokine, have been linked to susceptibility to many diseases, including cancer and immune dysfunction. Here, we explored the potential association between the IL-18 -607C/A (rs1946518) promoter region polymorphism and susceptibility to ischemic stroke (IS). This locus was amplified from peripheral blood samples of 386 IS patients (cases) and 364 healthy individuals (controls) by the polymerase chain reaction with sequence-specific primers. Significant differences were observed by the ?2 test in the -607C/A (rs1946518) genotype and allele frequencies between cases and controls (P < 0.05). Furthermore, after excluding for age, gender, smoking status, and hypertension, logistic regression indicated that IS susceptibility of -607C carriers increased 1.6 times (OR = 1.601, 95%CI = 1.148-2.233, P = 0.006) compared to -607A carriers. Additionally, similar increases in IS risk were noted for male patients or patients less than 65 years old. In conclusion, IL-18 -607C/A (rs1946518) promoter polymorphism is associated with IS susceptibility, and the C allele may confer increased IS risk.

SUBMITTER: Lu JX

PROVIDER: S-EPMC3854443 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature

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Correlation between interleukin-18 promoter -607C/A polymorphism and susceptibility to ischemic stroke.

Lu Jian-xia JX Lu Zhong-qian ZQ Zhang Shao-lan SL Zhi Juan J Chen Zheng-ping ZP Wang Wan-xiang WX

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20130524 6

Single nucleotide polymorphisms in the promoter region of interleukin-18 (IL-18), an inflammatory cytokine, have been linked to susceptibility to many diseases, including cancer and immune dysfunction. Here, we explored the potential association between the IL-18 -607C/A (rs1946518) promoter region polymorphism and susceptibility to ischemic stroke (IS). This locus was amplified from peripheral blood samples of 386 IS patients (cases) and 364 healthy individuals (controls) by the polymerase chai ...[more]

PMID: 23739747

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Dataset Information

Correlation between interleukin-18 promoter -607C/A polymorphism and susceptibility to ischemic stroke.

Publications

Correlation between interleukin-18 promoter -607C/A polymorphism and susceptibility to ischemic stroke.

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