Ontology highlight
ABSTRACT:
SUBMITTER: Schwenk RW
PROVIDER: S-EPMC3854991 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Molecular metabolism 20130925 4
Obesity is characterized as an excess accumulation of body fat resulting from a positive energy balance. It is the major risk factor for type 2 diabetes (T2D). The evidence for familial aggregation of obesity and its associated metabolic diseases is substantial. To date, about 150 genetic loci identified in genome-wide association studies (GWAS) are linked with obesity and T2D, each accounting for only a small proportion of the predicted heritability. However, the percentage of overall trait var ...[more]