Genetic and clinical markers of elevated liver fat content in overweight and obese Hispanic children.
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ABSTRACT:
SUBMITTER: Walker RW
PROVIDER: S-EPMC3855210 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Publications
Genetic and clinical markers of elevated liver fat content in overweight and obese Hispanic children.
Walker Ryan W RW Sinatra Frank F Hartiala Jaana J Weigensberg Marc M Spruijt-Metz Donna D Alderete Tanya L TL Goran Michael I MI Allayee Hooman H
Obesity (Silver Spring, Md.) 20130813 12
<h4>Objective</h4>Genetic variation in six genes has been associated with elevated liver fat and nonalcoholic fatty liver disease in adults. The influence of these genes on liver fat and whether a genetic risk score (GRS) would improve upon the ability of common clinical risk factors to predict elevated liver fat content (ELF) in Hispanic children was determined.<h4>Design and methods</h4>223 obese Hispanic children were genotyped for six SNPs. MRI was used to measure liver fat. A GRS was tested ...[more]
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