Shifting fitness landscapes in response to altered environments.
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ABSTRACT:
SUBMITTER: Hietpas RT
PROVIDER: S-EPMC3855258 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Publications
Shifting fitness landscapes in response to altered environments.
Hietpas Ryan T RT Bank Claudia C Jensen Jeffrey D JD Bolon Daniel N A DNA
Evolution; international journal of organic evolution 20130802 12
The role of adaptation in molecular evolution has been contentious for decades. Here, we shed light on the adaptive potential in Saccharomyces cerevisiae by presenting systematic fitness measurements for all possible point mutations in a region of Hsp90 under four environmental conditions. Under elevated salinity, we observe numerous beneficial mutations with growth advantages up to 7% relative to the wild type. All of these beneficial mutations were observed to be associated with high costs of ...[more]
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