Ontology highlight
ABSTRACT:
SUBMITTER: Mahanta N
PROVIDER: S-EPMC3855536 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20131007 41
Menaquinone (MK, vitamin K2) is a lipid-soluble molecule that participates in the bacterial electron transport chain. In mammalian cells, MK functions as an essential vitamin for the activation of various proteins involved in blood clotting and bone metabolism. Recently, a new pathway for the biosynthesis of this cofactor was discovered in Streptomyces coelicolor A3(2) in which chorismate is converted to aminofutalosine in a reaction catalyzed by MqnA and an unidentified enzyme. Here, we reconst ...[more]