Ontology highlight
ABSTRACT:
SUBMITTER: Joshi S
PROVIDER: S-EPMC6421580 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
ACS medicinal chemistry letters 20190215 3
Aminofutalosine synthase (MqnE) catalyzes an important rearrangement reaction in menaquinone biosynthesis by the futalosine pathway. In this Letter, we report the identification of previously unreported inhibitors of MqnE using a mechanism-guided approach. The best inhibitor shows efficient inhibitory activity against <i>H. pylori</i> (IC<sub>50</sub> = 1.8 ± 0.4 μM) and identifies MqnE as a promising target for antibiotic development. ...[more]