Ontology highlight
ABSTRACT:
SUBMITTER: d'Errico P
PROVIDER: S-EPMC3855775 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
d'Errico Paolo P Boido Marina M Piras Antonio A Valsecchi Valeria V De Amicis Elena E Locatelli Denise D Capra Silvia S Vagni Francesco F Vercelli Alessandro A Battaglia Giorgio G
PloS one 20131206 12
Loss of the survival motor neuron gene (SMN1) is responsible for spinal muscular atrophy (SMA), the most common inherited cause of infant mortality. Even though the SMA phenotype is traditionally considered as related to spinal motor neuron loss, it remains debated whether the specific targeting of motor neurons could represent the best therapeutic option for the disease. We here investigated, using stereological quantification methods, the spinal cord and cerebral motor cortex of ∆7 SMA mice du ...[more]