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A novel approach to quantifying ciliary physiology: microfluidic mixing driven by a ciliated biological surface.


ABSTRACT: From the lungs to the central nervous system, cilia-driven fluid flow plays a fundamental role in many facets of life. Yet, there are few quantitative methods for analysing the function of ciliated surfaces. Here, we report a novel microfluidic approach for quantifying the performance of a ciliated surface using mixing performance as an integrated readout.

SUBMITTER: Jonas S 

PROVIDER: S-EPMC3856250 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature

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A novel approach to quantifying ciliary physiology: microfluidic mixing driven by a ciliated biological surface.

Jonas Stephan S   Zhou Elaine E   Deniz Engin E   Huang Brendan B   Chandrasekera Kenny K   Bhattacharya Dipankan D   Wu Yu Y   Fan Rong R   Deserno Thomas M TM   Khokha Mustafa K MK   Choma Michael A MA  

Lab on a chip 20131101 21


From the lungs to the central nervous system, cilia-driven fluid flow plays a fundamental role in many facets of life. Yet, there are few quantitative methods for analysing the function of ciliated surfaces. Here, we report a novel microfluidic approach for quantifying the performance of a ciliated surface using mixing performance as an integrated readout. ...[more]

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