Ontology highlight
ABSTRACT:
SUBMITTER: Lian W
PROVIDER: S-EPMC3856571 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20130801 32
Protein-protein interactions represent a new class of exciting but challenging drug targets, because their large, flat binding sites lack well-defined pockets for small molecules to bind. We report here a methodology for chemical synthesis and screening of large combinatorial libraries of bicyclic peptides displayed on rigid small-molecule scaffolds. With planar trimesic acid as the scaffold, the resulting bicyclic peptides are effective for binding to protein surfaces such as the interfaces of ...[more]