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Cell-permeable bicyclic peptide inhibitors against intracellular proteins.

ABSTRACT: Cyclic peptides have great potential as therapeutic agents and research tools but are generally impermeable to the cell membrane. Fusion of cyclic peptides with a cyclic cell-penetrating peptide produces bicyclic peptides that are cell-permeable and retain the ability to recognize specific intracellular targets. Application of this strategy to protein tyrosine phosphatase 1B and a peptidyl-prolyl cis-trans isomerase (Pin1) isomerase resulted in potent, selective, proteolytically stable, and biologically active inhibitors against the enzymes.

SUBMITTER: Lian W

PROVIDER: S-EPMC4227718 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature

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Cell-permeable bicyclic peptide inhibitors against intracellular proteins.

Lian Wenlong W Jiang Bisheng B Qian Ziqing Z Pei Dehua D

Journal of the American Chemical Society 20140702 28

Cyclic peptides have great potential as therapeutic agents and research tools but are generally impermeable to the cell membrane. Fusion of cyclic peptides with a cyclic cell-penetrating peptide produces bicyclic peptides that are cell-permeable and retain the ability to recognize specific intracellular targets. Application of this strategy to protein tyrosine phosphatase 1B and a peptidyl-prolyl cis-trans isomerase (Pin1) isomerase resulted in potent, selective, proteolytically stable, and biol ...[more]

PMID: 24972263

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