Ontology highlight
ABSTRACT:
SUBMITTER: Rueckert EH
PROVIDER: S-EPMC3856665 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Rueckert E H EH Barker D D Ruderfer D D Bergen S E SE O'Dushlaine C C Luce C J CJ Sheridan S D SD Theriault K M KM Chambert K K Moran J J Purcell S M SM Madison J M JM Haggarty S J SJ Sklar P P
Molecular psychiatry 20120731 8
Several genome-wide association studies for bipolar disorder (BD) have found a strong association of the Ankyrin 3 (ANK3) gene. This association spans numerous linked single-nucleotide polymorphisms (SNPs) in an ~250-kb genomic region overlapping ANK3. The associated region encompasses predicted regulatory elements as well as two of the six validated alternative first exons, which encode distinct protein domains at the N-terminus of the protein also known as Ankyrin-G. Using RNA ligase-mediated ...[more]