Ontology highlight
ABSTRACT:
SUBMITTER: Di Fruscia P
PROVIDER: S-EPMC3856871 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
MedChemComm 20120301 3
Isoform selective inhibitors of the sirtuins (NAD<sup>+</sup>-dependent histone deacetylases) should enable an in depth study of the molecular biology underpinning these targets and how they are deregulated in diseases such as cancer and neurodegeneration. Herein, we present the discovery of structurally novel SIRT2 inhibitors. Hit molecule <b>8</b> was discovered through the chemical synthesis and biological characterization of a small-molecule compound library based around the 10,11-dihydro-5H ...[more]