Ontology highlight
ABSTRACT:
SUBMITTER: Qiao Y
PROVIDER: S-EPMC3857147 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Qiao Yu Y Giannopoulou Eugenia G EG Chan Chun Hin CH Park Sung-Ho SH Gong Shiaoching S Chen Janice J Hu Xiaoyu X Elemento Olivier O Ivashkiv Lionel B LB
Immunity 20130905 3
Synergistic activation of inflammatory cytokine genes by interferon-γ (IFN-γ) and Toll-like receptor (TLR) signaling is important for innate immunity and inflammatory disease pathogenesis. Enhancement of TLR signaling, a previously proposed mechanism, is insufficient to explain strong synergistic activation of cytokine production in human macrophages. Rather, we found that IFN-γ induced sustained occupancy of transcription factors STAT1, IRF-1, and associated histone acetylation at promoters and ...[more]