Ontology highlight
ABSTRACT:
SUBMITTER: Ayithan N
PROVIDER: S-EPMC3924795 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Ayithan Natarajan N Bradfute Steven B SB Anthony Scott M SM Stuthman Kelly S KS Dye John M JM Bavari Sina S Bray Mike M Ozato Keiko K
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 20131008 2
Ebola viruses (EBOV) can cause severe hemorrhagic disease with high case fatality rates. Currently, no vaccines or therapeutics are approved for use in humans. Ebola virus-like particles (eVLP) comprising of virus protein (VP40), glycoprotein, and nucleoprotein protect rodents and nonhuman primates from lethal EBOV infection, representing as a candidate vaccine for EBOV infection. Previous reports have shown that eVLP stimulate the expression of proinflammatory cytokines in dendritic cells (DCs) ...[more]