Ontology highlight
ABSTRACT:
SUBMITTER: Blaisdell TP
PROVIDER: S-EPMC3857215 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Blaisdell Thomas P TP Lee Sunggi S Kasaplar Pinar P Sun Xixi X Tan Kian L KL
Organic letters 20130903 18
Herein we report the site-selective silylation of the ribonucelosides. The method enables a simple and efficient procedure for accessing suitably protected monomers for automated RNA synthesis. Switching to the opposite enantiomer of the catalyst allows for the selective silylation of the 3'-hydroxyl, which could be used in the synthesis of unnatural RNA or for the analoging of ribonucelosides. Lastly, the procedure was extended to ribavirin a potent antiviral therapeutic. ...[more]