Ontology highlight
ABSTRACT:
SUBMITTER: Park HJ
PROVIDER: S-EPMC3857296 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Park Hyun-Joo HJ Kim Mi-Kyoung MK Kim Su-Ryun SR Bae Soo-Kyung SK Bae Moon-Kyoung MK
PloS one 20131209 12
The neuromedin B receptor (NMB-R), a member of the mammalian bombesin receptor family, is frequently overexpressed in various tumors. In the present study, we found that exposure to hypoxic conditions increases the levels of NMBR mRNA and protein in breast cancer cells, which are tightly regulated by hypoxia-inducible factor-1α (HIF-1α). We confirmed the effect of HIF-1α on NMBR transcription by performing an NMBR promoter-driven reporter assay and then identified a functional hypoxia-responsive ...[more]