Ontology highlight
ABSTRACT:
SUBMITTER: Zhao W
PROVIDER: S-EPMC4036260 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Zhao Wei W Chang Cunjie C Cui Yangyan Y Zhao Xiaozhi X Yang Jun J Shen Lan L Zhou Ji J Hou Zhibo Z Zhang Zhen Z Ye Changxiao C Hasenmayer Donald D Perkins Robert R Huang Xiaojing X Yao Xin X Yu Like L Huang Ruimin R Zhang Dianzheng D Guo Hongqian H Yan Jun J
The Journal of biological chemistry 20140228 16
Cancer cell proliferation is a metabolically demanding process, requiring high glycolysis, which is known as "Warburg effect," to support anabolic growth. Steroid receptor coactivator-3 (SRC-3), a steroid receptor coactivator, is overexpressed and/or amplified in multiple cancer types, including non-steroid targeted cancers, such as urinary bladder cancer (UBC). However, whether SRC-3 regulates the metabolic reprogramming for cancer cell growth is unknown. Here, we reported that overexpression o ...[more]