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Synthesis of Cyclic Guanidines via Silver-Catalyzed Intramolecular Alkene Hydroamination Reactions of N-Allylguanidines.

ABSTRACT: The silver-catalyzed hydroamination of tosyl-protected N-allylguanidines is described. These reactions provide substituted cyclic guanidines in high yields. The reactions are amenable to the construction of quaternary stereocenters as well as both monocyclic and bicyclic guanidine products.

SUBMITTER: Garlets ZJ

PROVIDER: S-EPMC4924592 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature

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Synthesis of Cyclic Guanidines via Silver-Catalyzed Intramolecular Alkene Hydroamination Reactions of N-Allylguanidines.

Garlets Zachary J ZJ Silvi Mattia M Wolfe John P JP

Organic letters 20160511 10

The silver-catalyzed hydroamination of tosyl-protected N-allylguanidines is described. These reactions provide substituted cyclic guanidines in high yields. The reactions are amenable to the construction of quaternary stereocenters as well as both monocyclic and bicyclic guanidine products. ...[more]

PMID: 27181609

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