Ontology highlight
ABSTRACT:
SUBMITTER: Liu J
PROVIDER: S-EPMC3857557 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Liu Jie J Lu Yuan-Fu YF Zhang Youcai Y Wu Kai Connie KC Fan Fang F Klaassen Curtis D CD
Toxicology and applied pharmacology 20130813 3
Oleanolic acid (OA) is a triterpenoids that exists widely in plants. OA is effective in protecting against hepatotoxicants. Whereas a low dose of OA is hepatoprotective, higher doses and longer-term use of OA produce liver injury. This study characterized OA-induced liver injury in mice. Adult C57BL/6 mice were given OA at doses of 0, 22.5, 45, 90, and 135 mg/kg, s.c., daily for 5 days, and liver injury was observed at doses of 90 mg/kg and above, as evidenced by increases in serum activities of ...[more]