Ontology highlight
ABSTRACT:
SUBMITTER: Lu YF
PROVIDER: S-EPMC6270117 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Molecules (Basel, Switzerland) 20130307 3
Oleanolic acid (OA) is a triterpenoid and a fantastic molecule with many beneficial effects. However, high-doses and long-term use can produce adverse effects. This study aimed to characterize the hepatotoxic potential of OA. Mice were given OA at doses of 100-3,000 µmol/kg (45-1,350 mg/kg), po for 10 days, and the hepatotoxicity was determined by serum biochemistry, histopathology, and toxicity-related gene expression via real-time RT-PCR. Animal body weight loss was evident at OA doses of 1,00 ...[more]