Ontology highlight
ABSTRACT:
SUBMITTER: Baum MM
PROVIDER: S-EPMC3857731 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Baum Marc M MM Butkyavichene Irina I Gilman Joshua J Kennedy Sean S Kopin Etana E Malone Amanda M AM Nguyen Cali C Smith Thomas J TJ Friend David R DR Clark Meredith R MR Moss John A JA
Journal of pharmaceutical sciences 20120522 8
Intravaginal delivery of microbicide combinations is a promising approach for the prevention of sexually transmitted infections, but requires a method of providing simultaneous, independent release of multiple agents into the vaginal compartment. A novel intravaginal ring (IVR) platform has been developed for simultaneous delivery of the reverse-transcriptase inhibitor tenofovir (TFV) and the guanosine analogue antiviral acyclovir (ACV) with independent control of release rate for each drug. The ...[more]