Ontology highlight
ABSTRACT:
SUBMITTER: Osumek JE
PROVIDER: S-EPMC3857770 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Osumek Jessica E JE Revesz Andrew A Morton Jude S JS Davidge Sandra T ST Hardy Daniel B DB
Reproductive sciences (Thousand Oaks, Calif.) 20130606 1
Given that hepatic glucose 6-phosphatase (G6Pase, involved in gluconeogenesis) has been demonstrated to be altered long term in animal models of intrauterine growth restriction (IUGR), we hypothesized that hypoxia in utero may regulate G6Pase expression via epigenetic mechanisms. To address this further, a rat model of maternal hypoxia leading to IUGR and impaired liver growth was utilized. In the 12-month-old male offspring of pregnant rat dams exposed to 11.5% atmospheric oxygen from gestation ...[more]