Ontology highlight
ABSTRACT:
SUBMITTER: Hatesuer B
PROVIDER: S-EPMC3857797 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Hatesuer Bastian B Bertram Stephanie S Mehnert Nora N Bahgat Mahmoud M MM Nelson Peter S PS Pöhlmann Stefan S Schughart Klaus K
PLoS pathogens 20131205 12
Annual influenza epidemics and occasional pandemics pose a severe threat to human health. Host cell factors required for viral spread but not for cellular survival are attractive targets for novel approaches to antiviral intervention. The cleavage activation of the influenza virus hemagglutinin (HA) by host cell proteases is essential for viral infectivity. However, it is unknown which proteases activate influenza viruses in mammals. Several candidates have been identified in cell culture studie ...[more]