Ubiquitin-specific peptidase 5, a target molecule of vialinin A, is a key molecule of TNF-? production in RBL-2H3 cells.
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ABSTRACT:
SUBMITTER: Yoshioka Y
PROVIDER: S-EPMC3857809 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Publications
Ubiquitin-specific peptidase 5, a target molecule of vialinin A, is a key molecule of TNF-α production in RBL-2H3 cells.
Yoshioka Yasukiyo Y Ye Yue Qi YQ Okada Kiyoshi K Taniguchi Kayoko K Yoshida Ayaka A Sugaya Kouichi K Onose Jun-ichi J Koshino Hiroyuki H Takahashi Shunya S Yajima Arata A Yajima Shunsuke S Abe Naoki N
PloS one 20131204 12
Tumor necrosis factor alpha (TNF-α), a central mediator of the inflammatory response, is released from basophilic cells and other cells in response to a variety of proinflammatory stimuli. Vialinin A is a potent inhibitor of TNF-α production and is released from RBL-2H3 cells. Ubiquitin-specific peptidase 5 (USP5), a deubiquitinating enzyme, was identified as a target molecule of vialinin A and its enzymatic activity was inhibited by vialinin A. Here we report production of TNF-α is decreased in ...[more]
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