Ontology highlight
ABSTRACT:
SUBMITTER: Rao VR
PROVIDER: S-EPMC3857970 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Rao Vidadala Ramasubba VR Muthenna Puppala P Shankaraiah Gundeti G Akileshwari Chandrasekhar C Babu Kothapalli Hari KH Suresh Ganji G Babu Katragadda Suresh KS Chandra Kumar Rotte Sateesh RS Prasad Kothakonda Rajendra KR Yadav Potharaju Ashok PA Petrash J Mark JM Reddy Geereddy Bhanuprakash GB Rao Janaswamy Madhusudana JM
European journal of medicinal chemistry 20120926
As a continuation of our efforts directed towards the development of anti-diabetic agents from natural sources, piplartine was isolated from Piper chaba, and was found to inhibit recombinant human ALR2 with an IC(50) of 160 μM. To improve the efficacy, a series of analogues have been synthesized by modification of the styryl/aromatic and heterocyclic ring functionalities of this natural product lead. All the derivatives were tested for their ALR2 inhibitory activity, and results indicated that a ...[more]