Ontology highlight
ABSTRACT:
SUBMITTER: Abbate V
PROVIDER: S-EPMC3858832 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Abbate Vincenzo V Liang Wanling W Patel Jayneil J Lan Yun Y Capriotti Luigi L Iacobucci Valentina V Bui Tam T TT Chaudhuri Poulami P Kudsiova Laila L Vermeer Louic S LS Chan Patrick F L PF Kong Xiaole X Drake Alex F AF Lam Jenny K W JK Bansal Sukhvinder S SS Mason A James AJ
Journal of controlled release : official journal of the Controlled Release Society 20131018 3
Cationic amphipathic pH responsive peptides possess high in vitro and in vivo nucleic acid delivery capabilities and function by forming a non-covalent complex with cargo, protecting it from nucleases, facilitating uptake via endocytosis and responding to endosomal acidification by being released from the complex and inserting into and disordering endosomal membranes. We have designed and synthesised peptides to show how Coulombic interactions between ionizable 2,3-diaminopropionic acid (Dap) si ...[more]