Ontology highlight
ABSTRACT:
SUBMITTER: Lam JK
PROVIDER: S-EPMC3309421 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Lam Jenny K W JK Liang Wanling W Lan Yun Y Chaudhuri Poulami P Chow Michael Y T MY Witt Katarzyna K Kudsiova Laila L Mason A James AJ
Journal of controlled release : official journal of the Controlled Release Society 20111126 2
Cationic amphipathic histidine rich peptides possess high plasmid DNA and siRNA delivery capabilities. To further understand the pH responsive siRNA delivery process and evaluate the capabilities of such peptides we have investigated their ability to mediate specific silencing of endogenous GAPDH gene activity in MCF-7 and A549 cells and compared this with plasmid DNA delivery. A substantial and selective reduction of both GAPDH activity and expression was achieved using pH responsive peptide ve ...[more]