Ontology highlight
ABSTRACT:
SUBMITTER: Fu M
PROVIDER: S-EPMC3859411 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Fu Ming M Landreville Solange S Agapova Olga A OA Wiley Luke A LA Shoykhet Michael M Harbour J William JW Heuckeroth Robert O RO
The Journal of clinical investigation 20131101 12
The retinoblastoma 1 (RB1) tumor suppressor is a critical regulator of cell cycle progression and development. To investigate the role of RB1 in neural crest-derived melanocytes, we bred mice with a floxed Rb1 allele with mice expressing Cre from the tyrosinase (Tyr) promoter. TyrCre+;Rb1fl/fl mice exhibited no melanocyte defects but died unexpectedly early with intestinal obstruction, striking defects in the enteric nervous system (ENS), and abnormal intestinal motility. Cre-induced DNA recombi ...[more]