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The enteric nervous system relays psychological stress to intestinal inflammation

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE229323 | GEO | 2023/05/25

REPOSITORIES: GEO

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The enteric nervous system relays psychological stress to intestinal inflammation [SnRNASeq_ENS]

Project description:Mental health profoundly impacts inflammatory responses in the body. This is particularly apparent in inflammatory bowel disease (IBD), where psychological stress is associated with disease flares. Here, we discover a critical role for the enteric nervous system (ENS) in mediating the aggravating effect of chronic stress on intestinal inflammation. We find that chronically elevated levels of glucocorticoids drive the generation of an inflammatory subset of enteric glia that promotes monocyte- and TNF-mediated colitis via CSF1. Additionally, glucocorticoids cause transcriptional immaturity in enteric neurons, acetylcholine deficiency, and dysmotility via TGFβ2. We verify the connection between the psychological state, intestinal inflammation, and dysmotility in two cohorts of human IBD patients. Together, these findings offer a mechanistic explanation for the impact of the brain on peripheral inflammation, define the ENS as a relay between psychological stress and gut inflammation, and suggest that stress management could serve as a valuable component of IBD care.

2023-05-25 | GSE229322 | GEO

The enteric nervous system relays psychological stress to intestinal inflammation [ScRNASeqCD45seq]

2023-05-25 | GSE229321 | GEO

The enteric nervous system relays psychological stress to intestinal inflammation [ColonBulkseq]

2023-05-25 | GSE229320 | GEO

The enteric nervous system relays psychological stress to intestinal inflammation

Project description:The enteric nervous system relays psychological stress to intestinal inflammation

| PRJNA963159 | ENA

The enteric nervous system relays psychological stress to intestinal inflammation [ColonBulkseq]

Project description:The enteric nervous system relays psychological stress to intestinal inflammation [ColonBulkseq]

| PRJNA963162 | ENA

The enteric nervous system relays psychological stress to intestinal inflammation [SnRNASeq_ENS]

Project description:The enteric nervous system relays psychological stress to intestinal inflammation [SnRNASeq_ENS]

| PRJNA963163 | ENA

The enteric nervous system relays psychological stress to intestinal inflammation [ScRNASeqCD45seq]

Project description:The enteric nervous system relays psychological stress to intestinal inflammation [ScRNASeqCD45seq]

| PRJNA963161 | ENA

Enteric Nervous System Derived IL-18 Orchestrates Mucosal Barrier Immunity

Project description:This SuperSeries is composed of the SubSeries listed below.

2019-12-12 | GSE141810 | GEO

Sequencing Reveals miRNAs Enriched in the Developing Mouse Enteric Nervous System

Project description:This SuperSeries is composed of the SubSeries listed below.

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The enteric nervous system promotes intestinal health by constraining microbiota composition.

Project description:Sustaining a balanced intestinal microbial community is critical for maintaining intestinal health and preventing chronic inflammation. The gut is a highly dynamic environment, subject to periodic waves of peristaltic activity. We hypothesized that this dynamic environment is a prerequisite for a balanced microbial community and that the enteric nervous system (ENS), a chief regulator of physiological processes within the gut, profoundly influences gut microbiota composition. We found that zebrafish lacking an ENS due to a mutation in the Hirschsprung disease gene, sox10, develop microbiota-dependent inflammation that is transmissible between hosts. Profiling microbial communities across a spectrum of inflammatory phenotypes revealed that increased levels of inflammation were linked to an overabundance of pro-inflammatory bacterial lineages and a lack of anti-inflammatory bacterial lineages. Moreover, either administering a representative anti-inflammatory strain or restoring ENS function corrected the pathology. Thus, we demonstrate that the ENS modulates gut microbiota community membership to maintain intestinal health.

| S-EPMC5331947 | biostudies-literature

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