Microcephaly genes and risk of late-onset Alzheimer disease.
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ABSTRACT:
SUBMITTER: Erten-Lyons D
PROVIDER: S-EPMC3136560 | biostudies-literature | 2011 Jul-Sep
REPOSITORIES: biostudies-literature
Publications
Microcephaly genes and risk of late-onset Alzheimer disease.
Erten-Lyons Deniz D Wilmot Beth B Anur Pavana P McWeeney Shannon S Westaway Shawn K SK Silbert Lisa L Kramer Patricia P Kaye Jeffrey J
Alzheimer disease and associated disorders 20110701 3
Brain development in the early stages of life has been suggested to be one of the factors that may influence an individual's risk of Alzheimer disease (AD) later in life. Four microcephaly genes, which regulate brain development in utero and have been suggested to play a role in the evolution of the human brain, were selected as candidate genes that may modulate the risk of AD. We examined the association between single nucleotide polymorphisms tagging common sequence variations in these genes a ...[more]
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